Here's an minimum possible example to use mod_perl2:

<VirtualHost *>
        ServerName myapp.example.org
        ServerAdmin  admin@example.org

        DocumentRoot /myapp

        SetHandler perl-script
        PerlHandler Jifty::Script::ModPerl2
        <Directory /myapp>
                Allow from All
        </Directory>
</VirtualHost>

Here's another example config that comes with pretty aggresive Expires header setting and gzip its output for best front-end performance.

<VirtualHost *>
        ServerName myapp.example.org
        ServerAdmin  admin@example.org

        DocumentRoot /myapp

        SetHandler perl-script
        PerlHandler Jifty::Script::ModPerl2

        <Directory /myapp>
                Allow from All

                ExpiresActive On
                ExpiresByType image/png A864000000
                ExpiresByType application/x-javascript A864000000
                ExpiresByType text/css A864000000

                SetOutputFilter DEFLATE
                BrowserMatch ^Mozilla/4 gzip-only-text/html
                BrowserMatch ^Mozilla/4\.0[678] no-gzip
                BrowserMatch \bMSI[E] !no-gzip !gzip-only-text/html
                SetEnvIfNoCase Request_URI \.(?:gif|jpe?g|png)$ no-gzip dont-vary
                Header append Vary User-Agent env=!dont-vary
        </Directory>

</VirtualHost>