Here's an example config using mod_perl2. It comes with Expires header setting for best front-end performance.

<VirtualHost *>
        ServerName myapp.example.org
        ServerAdmin  admin@example.org

        DocumentRoot /myapp

        SetHandler perl-script
        PerlHandler Jifty::Script::ModPerl2

        <Directory /myapp>
                Allow from All

                ExpiresActive On
                ExpiresByType image/png A864000000
                ExpiresByType application/x-javascript A864000000
                ExpiresByType text/css A864000000

                SetOutputFilter DEFLATE
                BrowserMatch ^Mozilla/4 gzip-only-text/html
                BrowserMatch ^Mozilla/4\.0[678] no-gzip
                BrowserMatch \bMSI[E] !no-gzip !gzip-only-text/html
                SetEnvIfNoCase Request_URI \.(?:gif|jpe?g|png)$ no-gzip dont-vary
                Header append Vary User-Agent env=!dont-vary
        </Directory>

        <Location /__jifty/>
                Allow from All
                SetHandler perl-script
                PerlHandler Jifty::Script::ModPerl2
                ExpiresActive On
                ExpiresDefault "access plus 10 years"
        </Location>
</VirtualHost>