Here's an example to run Jifty app with nginx. It still has some problem. Please read to the bottom of this page before you try it.

Config: (Replace APP to your application root path)

worker_processes  1;

events {
    worker_connections  1024;
}

http {
    include       /opt/local/etc/nginx/mime.types;
    default_type  application/octet-stream;

    keepalive_timeout  65;

    gzip  on;
    gzip_http_version 1.0;
    gzip_comp_level 2;
    gzip_proxied any;
    gzip_types text/plain text/html text/css application/x-javascript text/xml application/xml application/xml+rss text/javascript;

    fastcgi_param  SCRIPT_NAME        $fastcgi_script_name;
    fastcgi_param  PATH_INFO          $fastcgi_script_name;
    fastcgi_param  GATEWAY_INTERFACE  CGI/1.1;
    fastcgi_param  SERVER_SOFTWARE    nginx;
    fastcgi_param  QUERY_STRING       $query_string;
    fastcgi_param  REQUEST_METHOD     $request_method;
    fastcgi_param  CONTENT_TYPE       $content_type;
    fastcgi_param  CONTENT_LENGTH     $content_length;
    fastcgi_param  REQUEST_URI        $request_uri;
    fastcgi_param  DOCUMENT_URI       $document_uri;
    fastcgi_param  DOCUMENT_ROOT      $document_root;
    fastcgi_param  SERVER_PROTOCOL    $server_protocol;
    fastcgi_param  REMOTE_ADDR        $remote_addr;
    fastcgi_param  REMOTE_PORT        $remote_port;
    fastcgi_param  SERVER_ADDR        $server_addr;
    fastcgi_param  SERVER_PORT        $server_port;
    fastcgi_param  SERVER_NAME        $server_name;

    server {
        listen       80;
        server_name  localhost;

        root   /APP/share/web/;

        location ~ ^/static/ {
            expires 10y;
        }

        location / {
             if (-f $request_filename) {
                 break;
             }

             fastcgi_pass   localhost:9000;
        }
    }
}

You need to manually start jifty fastcgi server with this command;

FCGI_SOCKET_PATH="localhost:9000" bin/jifty fastcgi

However, there is one important issue of this config. Jifty internally serves many javascript that does not live under APP/share/web/static/, You need to localized ALL those files in order to make it severable by nginx:

cp -rn /usr/local/lib/perl5/site_perl/5.8.8/auto/Jifty/web/static/* share/web/static

Usually this gets delegate to Jifty's fastcgi handler and do the right thing, but somehow it doesn't do so in Nginx. I guess this is fine because serving static files without going through perl is actually faster.